Clinical data becomes useful when it remains traceable, reusable, and reviewable.
Regulated biomedical work depends on secure data flow, reproducible analysis, traceable decisions, clear documentation, and outputs that support review, audit, and reuse. My work connects clinical genomics, EHR-linked data, multi-omics, governance, secure compute, and structured reporting.
Clinical data workflows need clear links between source data, processing, analysis, interpretation, and final output.
Biomedical data becomes more valuable when it can be reused safely across research, clinical, governance, and translational contexts.
Reports, databases, pipelines, and documentation need enough structure to support review, quality control, and later audit.
Clinical infrastructure has to satisfy clinicians, data scientists, bioinformaticians, governance teams, software teams, and decision-makers at the same time.
Qualifying variant database. The open standard for variant interpretation, with trusted QV sets to enhance clarity and reproducibility in genetics.
PanelAppRex AI. Harmonised disease-gene panels from structured clinical and genetic queries. For humans and for machines.
Patient-level data, EHR-linked workflows, phenotype-linked molecular data, cohort definition, missingness, data quality, and longitudinal data structures.
High-performance computing, Unix, Linux, encrypted storage, controlled file transfer, AWS, Azure, Docker, Singularity or Apptainer, and structured data environments.
Good Clinical Practice, GLP-aware laboratory delivery, ICH-aligned documentation discipline, audit-ready workflows, traceability, version control, and quality records.
R, Python, Git, workflow automation, reproducible reports, machine-readable outputs, versioned pipelines, QC checks, and structured analytical documentation.
SQL, PostgreSQL, APIs, HTML reporting, Next.js, React, TypeScript, Supabase, authenticated systems, and user-facing scientific platforms.
Clinical research, data governance, genomics, bioinformatics, data science, neonatology, intensive care, scientific leadership, and external partner coordination.
Genomic Vault: long-term custody and controlled access for genomics and precision medicine.
VCFheader: parsing VCF headers and generating structured standalone HTML reports, described in Lawless (2026).
Qualifying variant database: reusable YAML criteria for reproducible genomic variant interpretation, published in Lawless et al (2026).
ORCID record:
0000-0001-8496-3725
Application of qualifying variants for genomic analysis. Bioinformatics, 42(2), btaf676, 2026.
Germline TET2 loss of function causes childhood immunodeficiency and lymphoma. Blood, 136(9), 1055-1066, 2020.
Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder. eLife, 10(), , 2021.
A case of adult-onset Still's disease caused by a novel splicing mutation in TNFAIP3 successfully treated with tocilizumab. Frontiers in Immunology, 9(), , 2018.
Designed analytical workflows and clinical research databases for paediatric critical care, rare disease, genomics, multi-omics, and EHR-linked research.
Approximately 1,000 children, more than 100 TB of biomedical data, three hospitals, SwissPedHealth National Data Stream, Swiss Pediatric Sepsis Study, governance-facing workflows.
Built reproducible computational workflows for infectious, inflammatory, and translational studies across Swiss and international collaborators.
Cohorts up to 5,000 participants, multidisciplinary teams across EPFL, ETH Zürich, Swiss university hospitals, Swiss TPH, and international partners.
Delivered biomarker and assay workflows in a regulated bioanalytical laboratory serving global clinical trial programmes.
Quality-controlled assay delivery, documentation discipline, biomarker workflows, regulated laboratory operations, development-stage decision support.
Clinical and regulated data teams need evidence systems that can be inspected, reused, and defended. The useful output is not only analysis, but a reliable chain from source data to structured decision support.
